The Big Apple takes on Type 1 Diabetes

Diabetes pathogenesis, physiology of insulin action, pancreatic beta-cell dysfunction

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Human and large animal islet isolation, islet cell subtype purification

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Alpha cell physiology and islet transplantation

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Immune tolerance, disease modeling and immunotherapy in T1D

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Autoimmune diseases and autoantigens; immunopathogenesis of T1D; humanized disease models; immunomodulatory therapies

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Beta-cell regeneration and heterogeneity; G-Protein Coupled Receptors

Islet Neurobiology; Beta-cell growth and function

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Beta cell development, hPSC disease modeling, CRISPR and human genetics

Useful Links

Huangful Lab website
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Beta cell inflammation

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Beta-cell proliferation, beta-cell demise, glucolipotoxicity, cytokine-induced toxicity, beta-cell mass preservation.

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Human beta cell regeneration, drug discovery and development

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Thymic T cell development and β-cell destruction in Humanized mice

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Autologous immune-resistant islets for transplantation therapy

Useful Links

Zhou Lab website
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